Workshop program

Program Overview

For a digital version of the abstract booklet click here.

Friday, April 29

Time Session title
08:50 - 10:30 Adaptive Design 3
10:30 - 11:00 Coffee Break
11:00 - 12:40 Multiple Testing 2
12:40 - 13:50 Lunch Break
13:50 - 15:30 Adaptive Design 4
15:30 - 16:00 Coffee Break
16:00 - 16:20 AG Meeting
16:20 - 17:35 Multiple Testing 3

Information about the guided tour

We have organized a guided tour of the Pallazzo Bo - the historic part of the University. It will start at 18:20 at the main University building (Bo in the Map below), which is about a 10 minute walk from the conference venue. We will walk there together, leaving from the conference venue directly after the end of the last session. The tour will take about 40 minutes. Participation is free of cost, due to limited capacities only attendants who have successfully registered for the tour may attend. Please bring the coupon that you receive with your registration materials.

Information about the dinner

The dinner will be hosted at the restaurant 'Isola di Caprera' (Via Marsilio da Padova, 11/15, see map below) and start at 20:00. We will be offered a four course menu of local sea food specialties. The price of the menu is 35 Euro. An accompanying selection of drinks (Wine, Water, Coffee) are included in the price. For convenience we ask you to pay for the dinner in cash at the registration desk. Other menu options or, if you have any dietary restrictions are available on request. Please let us know in advance, so we can make sure that your needs are accommodated.

Thursday, April 28

13:00 - 14:40: Multiple Testing 1

Chair: Gerhard Hommel

  1. Fortunato Pesarin
    An Analysis of Union-Intersection and Intersection-Union Tests for Equivalence and Non-Inferiority
    University of Padua, Italy

  2. Helmut Finner, Veronika Gontscharuk
    Two-sample Kolmogorov-Smirnov type tests and local levels
    Deutsches Diabetes-Zentrum (DDZ), Leibniz-Zentrum für Diabetes-Forschung an der Heinrich-Heine-Universität Düsseldorf, Germany

  3. Veronika Gontscharuk, Helmut Finner
    Weighted Kolmogorov-Smirnov tests in one- and two-sample problems
    German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich-Heine-University Dusseldorf, Germany

  4. Robin Ristl, Dong Xi, Ekkehard Glimm, Martin Posch
    Optimal exact tests for multiple binary endpoints
    Medical University of Vienna, Austria

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15:10 - 16:25: Adaptive Design 1

Chair: Meinhard Kieser

  1. Silke Jörgens, Tobias Mielke
    Considerations On Futility Rules For Adaptive Dose-Finding Designs
    ICON Clinical Research, Germany

  2. Deepak Parashar, Jack Bowden, Colin Starr, Lorenz Wernisch, Adrian Mander
    Optimal designs for group sequential biomarker-enrichment oncology trials.
    University of Warwick, United Kingdom

  3. Federico Andreis, Marco Bonetti
    An Adaptive Enrollment Strategy for the Identification of Maximum Treatment Effect Regions
    Bocconi University, Milan, Italy

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16:45 - 18:00: Adaptive Design 2

Chair: Gernot Wassmer

  1. Willi Maurer, Byron Jones, Ying Chen
    A robust combination test for sample size adaptation in a two-stage cross-over trial for Average Bioequivalence
    Novartis Pharma, Switzerland

  2. Kevin Kunzmann, Meinhard Kieser
    Optimal Adaptive Two-Stage Designs for Single-Arm Trials with Binary Endpoint: Recent Improvements and Consistent Inference
    Heidelberg University, Germany

  3. Klemens Weigl, Ivo Ponocny
    ReThink: Adaptive Two-Stage Designs applied with PsyStatAlpha in Psychological Research
    JKU Linz, Austria

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Friday, April 29

08:50 - 10:30: Adaptive Design 3

Chair: Florian Klinglmueller

  1. Josephine Khan, Peter Kimani, Nigel Stallard, Ekkehard Glimm.
    Selection bias and correlation in seamless phase II/III clinical trials with survival data
    University of Warwick, United Kingdom

  2. Matthias Brückner, Werner Brannath
    Interim Decisions in Adaptive Clinical Trials with Time-to-event Surrogate and Primary Endpoints
    Universität Bremen, Germany

  3. Thomas Asendorf, Robin Henderson, Heinz Schmidli, Tim Friede
    Blinded Sample Size Reestimation for Time Dependent Negative Binomial Counts with Incomplete Follow-up
    University Medical Center Göttingen, Germany

  4. Roland Gera, Tim Friede
    Blinded sample size reestimation for Adaptive Enrichment designs with Longitudinal Data
    Universitätsmedizin Göttingen, Germany

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11:00 - 12:40: Multiple Testing 2

Chair: Jelle Goeman

  1. Arnold Janssen
    Martingale approach for multiple testing and FDR control
    Heinrich-Heine University Duesseldorf, Germany

  2. Aldo Solari, Jelle J. Goeman
    Minimally Adaptive BH: a tiny but uniform improvement of the procedure of Benjamini and Hochberg
    University of Milano-Bicocca, Italy

  3. Jesse Hemerik
    False discovery proportion estimation by permutations: confidence for SAM
    Leiden University Medical Center, Netherlands

  4. Djalel-Eddine Meskaldji, Stephan Morgenthaler
    Thresholding of ordered p-values: which error rate is being controlled?
    EPFL, Switzerland

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13:50 - 15:30: Adaptive Design 4

Chair: Andreas Faldum

  1. Yida Chiu
    Designs and Estimation in Clinical trails with Subpopulation Selection
    Lancaster University, United Kingdom

  2. Laura Kohlhas, Meinhard Kieser
    Timing of subgroup selection in adaptive enrichment designs
    Univeristy of Heidelberg, Germany

  3. Johannes Krisam, Meinhard Kieser
    Optimal Subgroup Selection Rules in Adaptive Oncology Trials with Time-to-Event Outcome
    University of Heidelberg, Germany

  4. Marius Placzek, Tim Friede
    Analysis, Sample Size Calculation and Recalculation in Designs with Multiple Nested Subgroups
    University Medical Center Göttingen, Germany

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16:20 - 17:35: Multiple Testing 3

Chair: Livio Finos

  1. Kornelius Rohmeyer, Werner Brannath, Sarah Nanninga
    The Populationwise Error Rate - A More Liberal Error Rate for Multiplicity Adjustment in Enrichment Designs
    University of Bremen, Germany

  2. Natalia Sirotko-Sibirskaya, Prof. Dr. Thorsten Dickhaus, Prof. Dr. Markus Pauly
    Simultaneous Statistical Inference in Dynamic Factor Models (Estimation, Simulation, Application)
    University of Bremen, Germany

  3. Fang Wan, Wei Liu; Frank Bretz; Yang Han;
    Confidence Sets for Optimal Factor Levels of a Response Surface
    Lancaster University, United Kingdom

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